Lecithinized superoxide dismutase reduces cold ischemia-induced chronic allograft dysfunction
نویسندگان
چکیده
منابع مشابه
[Development of lecithinized superoxide dismutase as a drug for IPF].
Idiopathic pulmonary fibrosis (IPF) and chronic obstructive pulmonary disease (COPD) are thought to involve lung injury induced by reactive oxygen species (ROS), in particular superoxide anion. The enzyme, superoxide dismutase (SOD) catalyses the dismutation of superoxide anion to hydrogen peroxide. Lecithinized SOD (PC-SOD) has overcome a number of previous clinical limitations of SOD, includi...
متن کاملTherapeutic effect of lecithinized superoxide dismutase against colitis.
Ulcerative colitis (UC) involves intestinal mucosal damage induced by reactive oxygen species (ROS), in particular, superoxide anion. Superoxide dismutase (SOD) catalyzes dismutation of superoxide anion to hydrogen peroxide, which is subsequently detoxified by catalase. Lecithinized SOD (PC-SOD) is a new modified form of SOD that has overcome previous clinical limitations of SOD. In this study,...
متن کاملA lecithinized superoxide dismutase (PC-SOD) improves ulcerative colitis
OBJECTIVE To assess the safety and efficacy of lecithinized superoxide dismutase (PC-SOD) in patients with ulcerative colitis (UC). METHOD PC-SOD was injected once daily at doses of 40 mg (n = 22) and 80 mg (n = 20) for a total treatment period of 4 weeks. Efficacy was assessed by UC-Disease Activity Index (DAI) total score. All side effects were recorded and investigated. RESULTS At 4 week...
متن کاملTherapeutic effect of lecithinized superoxide dismutase on pulmonary emphysema.
No medication exists that clearly improves the mortality of chronic obstructive pulmonary disease (COPD). Oxidative molecules, in particular superoxide anions, play important roles in the COPD-associated abnormal inflammatory response and pulmonary emphysema, which arises because of an imbalance in proteases and antiproteases and increased apoptosis. Superoxide dismutase (SOD) catalyzes the dis...
متن کاملTherapeutic effect of lecithinized superoxide dismutase (PC-SOD) on bleomycin-induced pulmonary fibrosis
Graduate School of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto 862-0973, Japan Department of Internal Medicine, Division of Respiratory, Infection and Oncology, Nippon Medical School, Tokyo 113-8602, Japan. Department of Respiratory Medicine, Tohoku University Graduate School of Medicine, Sendai 980-8575, Japan. Department of Medicine, Jichi Medical University, Tochigi 32...
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ژورنال
عنوان ژورنال: Kidney International
سال: 2002
ISSN: 0085-2538
DOI: 10.1046/j.1523-1755.2002.00217.x